Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Utility of Basophil Activation Test in a Case of Daisaikoto- and Yokukansan-induced Lung Injury
Tomoko KawaharaMunehiro YamaguchiChisato OnitsukaTomoyuki KimuraTetsuya HommaHironori Sagara
ジャーナル オープンアクセス 早期公開

論文ID: 6296-20


Drug-induced lung injury is defined as a respiratory disorder. The usefulness of the basophil activation test (BAT) for drug allergy-related cases was recently reported. The patient was an 82-year-old woman who had been taking Daisaikoto and Yokukansan (herbal medicines) 3 months before developing dry cough. She was admitted to our hospital with an initial diagnosis of pneumonia with elevated serum LDH, KL-6, and IgE. Chest CT showed bilateral GGOs. Her BAL fluid showed increased eosinophils. Finally, a BAT was positive for both medications. Based on the findings, the patient was diagnosed with Daisaikoto- and Yokukansan-induced lung injury. The current case suggests that the BAT may be useful for the diagnosis of drug-induced lung injury.

© 2021 by The Japanese Society of Internal Medicine