Estrogen Therapy in a Male Patient with Chronic Hepatitis C and Irradiation-induced Testicular Dysfunction

Ichiro SHIMIZU; Toshihiro OMOYA; Yuki KONDO; Yoshihiro KUSAKA; Akemi TSUTSUI; Hiroshi SHIBATA; Hirohito HONDA; Nobuya SANO; Susumu ITO

doi:10.2169/internalmedicine.40.100

Ichiro SHIMIZU, Toshihiro OMOYA, Yuki KONDO, Yoshihiro KUSAKA, Akemi TSUTSUI, Hiroshi SHIBATA, Hirohito HONDA, Nobuya SANO, Susumu ITO

著者情報

キーワード: hepatic fibrosis, hepatic iron concentration, hepatitis C virus

ジャーナルフリー

2001 年 40 巻 2 号 p. 100-104

DOI https://doi.org/10.2169/internalmedicine.40.100

詳細

抄録

We report an 18-year-old male patient who developed chronic hepatitis C after blood transfusion and had testicular dysfunction after irradiation for a testicular relapse of childhood acute lymphocytic leukemia after cessation of maintenance therapy, and the initiation of testosterone replacement therapy at puberty. Concomitant administration of estradiol resulted in a reduction in serum alanine aminotransferase and ferritin levels and hepatic iron concentration and staining after 2 years of estrogen therapy, although interferon therapy was withdrawn because of adverse effects. This observation suggests that endogenous estradiol may play a beneficial role in male patients with chronic hepatitis C.
(Internal Medicine 40:100-104, 2001)

責任著者(Corresponding author)

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