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Munehiko MORISHITA
2001 年 40 巻 2 号 p.
77
発行日: 2001年
公開日: 2006/03/27
ジャーナル
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Akira MATSUMORI
2001 年 40 巻 2 号 p.
78-79
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Iwao SEKIGAWA, Hitoshi OGASAWARA, Hiroshi KANEKO, Takashi HISHIKAWA, H ...
2001 年 40 巻 2 号 p.
80-86
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
The investigation of human retroviruses has shown dramatic progress since the discovery of human immunodeficiency virus (HIV). These studies have also contributed to the exploration of the role of retroviruses, including endogenous retroviruses, in the induction of autoimmune diseases such as systemic lupus erythematosus (SLE). This review describes the potential role of retroviruses in autoimmunity, based on recent findings including our own results.
(Internal Medicine 40: 80-86, 2001)
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Hiroshi DATE
2001 年 40 巻 2 号 p.
87-95
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
Lung transplantation has been performed successfully outside Japan since 1983 in patients with end-stage lung disease. More than 9, 000 lung transplants have been reported in The Registry of the International Society for Heart and Lung Transplantation. In contrast, a transplant law became effective in Japan only recently, and four universities were designated as official lung transplant centers (Okayama, Osaka, Kyoto and Tohoku Universities). In October 1998, the first successful living-donor lobar lung transplantation was performed at Okayama University. Since then, seven lung transplants (four from living donors and three from cadaveric donors) have been successfully performed in Japan. Although lung transplantation offers acceptable prospects for 5-year survival, chronic rejection and donor shortage remain to be major problems. In an effort to address the donor shortage issue, living-donor lobar lung transplantations have been performed with satisfactory intermediate survival and functional results.
(Internal Medicine 40: 87-95, 2001)
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Kentaro YAMASHITA, Masayo HOSOKAWA, Sae HIROHASHI, Yoshiaki ARIMURA, T ...
2001 年 40 巻 2 号 p.
96-99
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
A 59-year-old man was admitted presenting systemic rash and muscle weakness. He was diagnosed to have dermatomyositis and a check was made for internal malignancy. Gastrointestinal endoscopy revealed a Borrmann type II tumor on the middle body of the stomach. Biopsy specimens showed a well differentiated adenocarcinoma, and total gastrectomy was performed. The final diagnosis was moderately differentiated adenocarcinoma invading into the proper muscular layer, with metastases to regional lymph nodes. Most of the neoplastic cells were shown to be positive for Epstein-Barr virus by means of EBV-encoded RNA in situ hybridization. The symptoms of dermatomyosi tis disappeared completely after surgery.
(Internal Medicine 40: 96-99, 2001)
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Ichiro SHIMIZU, Toshihiro OMOYA, Yuki KONDO, Yoshihiro KUSAKA, Akemi T ...
2001 年 40 巻 2 号 p.
100-104
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
We report an 18-year-old male patient who developed chronic hepatitis C after blood transfusion and had testicular dysfunction after irradiation for a testicular relapse of childhood acute lymphocytic leukemia after cessation of maintenance therapy, and the initiation of testosterone replacement therapy at puberty. Concomitant administration of estradiol resulted in a reduction in serum alanine aminotransferase and ferritin levels and hepatic iron concentration and staining after 2 years of estrogen therapy, although interferon therapy was withdrawn because of adverse effects. This observation suggests that endogenous estradiol may play a beneficial role in male patients with chronic hepatitis C.
(Internal Medicine 40:100-104, 2001)
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Takayuki FUJIWARA, Katsuyuki KIURA, Koji OCHI, Hiromi MATSUBARA, Hiros ...
2001 年 40 巻 2 号 p.
105-109
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
Interferon-a (IFN-α) has been widely used for treatment of chronic hepatitis C in Japan. In general, cardiovascular adverse reactions are rare in association with IFN-α therapy. Here, a 64-year-old man with chronic active hepatitis C complained of fatigue, palpitation and depression, and developed atrial fibrillation with prominent negative T waves during IFN-α therapy. Echocardiogram showed septal and apical hypertrophy. Three days after discontinuation of IFN-α, subjective symptoms and atrial fibrillation subsided. It is unclear whether or not IFN-α induced the giant negative T waves with apical hypertrophy. We might observe the developing course of hepatitis C virus (HCV) - related myocardial hypertrophy by chance. Cardiovascular toxicity should be carefully monitored during IFN-α therapy even in patients with minor cardiac disease, such as premature ventricular contracture (PVC) and mild hypertension.
(Internal Medicine 40: 105-109, 2001)
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Shimon ISHIDA, Haruhiko ISOTANI, Keiichi KAMEOKA, Toshiyuki KISHI
2001 年 40 巻 2 号 p.
110-113
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
We describe a 27-year-old woman with familial idiopathic hypoparathyroidism, bilateral sensorineural deafness and right renal aplasia. There was a family history of deafness in her father and two other family members with sensorineural deafness, one of whom had hypoparathyroidism. To our knowledge, there have been four previous reports of idiopathic hypoparathyroidism associated with sensorineural deafness and renal dysplasia. The clinical features were not identical to any of the four previous reports. Although no chromosome abnormalities were present in the patient using standard trypsin G-banding analysis, we speculate that some common genetic mutation caused hypoparathyroidism, sensorineural deafness and renal dysplasia.
(Internal Medicine 40: 110-113, 2001)
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Yasukazu KIMURA, Minoru KAWAMURA, Masahiko OWADA, Takuya FUJIWARA, Chi ...
2001 年 40 巻 2 号 p.
114-117
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
A 58-year-old woman was admitted to our hospital because of renal dysfunction that continued to progress even after withdrawal of cefdinir, the presumed cause of acute renal failure. Renal histologic findings included interstitial fibrosis accompanied by moderate lymphocytic infiltration, and tubular atrophy with reduced numbers of epithelial cells. Mesangial cells and glomerular basement membranes were nearly normal. Scintigraphy with
67gallium disclosed diffuse abnormal accumulation in both kidneys. A lymphocyte stimulation test with cefdinir was positive. The patient was diagnosed with acute tubulointerstitial nephritis caused by cefdinir. Serum creatinine concentrations continued to rise after withdrawal of the drug, but steroid therapy was effective in normalizing renal function.
(Internal Medicine 40: 114-117, 2001)
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Hiroshi MURATA, Hiroshi YOSHIMOTO, Masatoshi MASUO, Hitoshi TOKUDA, Sh ...
2001 年 40 巻 2 号 p.
118-123
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
A 40-year-old man on hemodialysis was admitted due to dyspnea and chest pain and was diagnosed with pneumonia and pericarditis. Ampicillin was administered, but thereafter severe septic shock developed. The fulminant type of pneumonia progressed rapidly, and he died only 48 hours after the onset of symptoms. The autopsy and sputa culture revealed pneumonia due to
Aeromonas hydrophila. The source of this infection remained unkown. Interestingly, there were two types of
A. hydrophila found during such a short period. The physician should suspect this disease by questioning the patient's history. Early treatment with adequate antibiotics is the only means of saving such a patient's life.
(Internal Medicine 40: 118-123, 2001)
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Kosuke KASHIWABARA, Hiroyuki NAKAMURA
2001 年 40 巻 2 号 p.
124-126
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
A 74-year-old woman was admitted with an asthma attack. She had a 40-year history of sinusitis, nasal polyp and analgesic-induced asthma; however, asthma had never occurred when she used a 0.3% ketoprofen adhesive patch (Mohrus
®) for stiff shoulder or lumbago. In the hospital, a life-threatening asthma attack suddenly occurred two and a half hours after application of a 2.0% ketoprofen adhesive tape (Mohrus tape
®) to her shoulder. She was treated with bronchodilator and glucocorticoid and extubated after 20 hours. A drug lymphocyte stimulating test (DLST) was strongly positive for ketoprofen. We suspected that drug-induced hypersensitivity coexisted in the present case, but it was not clear whether or not the hypersensitivity was related to the pathogenesis of analgesic-induced asthma.
(Internal Medicine 40: 124-126, 2001)
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Kosuke KASHIWABARA, Masakazu TOYONAGA, Yuji YAMAGUCHI, Hiroyuki NAKAMU ...
2001 年 40 巻 2 号 p.
127-130
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
A 49-year-old woman consulted our hospital for evaluation of a tumor with cavitation in the S
6 segment of the right lung. She was given a diagnosis of pulmonary tuberculoma because percutaneous needle aspiration cytology revealed epithelioid cells with a background of necrosis. However, a diagnosis of large cell carcinoma with central necrosis (p-T2NOMO) was established by thoracoscopic lung biopsy six months later. Pathological findings of surgical resection specimens showed that epithelioid cell granulomas adjacent to the neoplasm had a sarcoid reaction and the necrosis was related to the rapidly growing tumor because there was no clinical evidence of systemic sarcoidosis and pulmonary mycobacterial or fungal infection. This is the first report in which sarcoid reactions were recognized in a primary large cell carcinoma.
(Internal Medicine 40: 127-130, 2001)
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Kenji TSUSHIMA, Shigeru KOYAMA, Mayumi UENO, Keisaku FUJIMOTO, Takeo I ...
2001 年 40 巻 2 号 p.
131-134
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
We describe a patient with McArdle disease who developed rhabdomyolysis triggered by a bronchial asthmatic attack. A 64-year-old man had chronic pulmonary emphysema with asthma, and an asthmatic attack led to severe rhabdomyolysis that required continuous hemodiafiltration. After 2 years, a physical examination revealed atrophy of the extremities compared with previous examinations, especially of the intercostal muscles. During that time, he suffered two severe bronchial asthmatic attacks. His serum level of creatinine kinase remained between 4, 000 and 7, 000 IU/
l when he did not suffer from asthmatic attacks and rhabdomyolysis had abated. Therefore, we suspected that his recent muscle atrophy was caused by asthmatic attacks, and discussed the possibility of his respiratory muscle weakness due to McArdle disease in relation to his severe bronchial asthmatic attacks as well as chronic obstructive pulmonary disease.
(Internal Medicine 40: 131-134, 2001)
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Kazuhiro TASHIMA, Eiichiro UYAMA, Yoichiro HASHIMOTO, Toshiro YONEHARA ...
2001 年 40 巻 2 号 p.
135-139
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
Susac's syndrome is a rare disorder characterized by the triad of microangiopathy of the brain and retina with hearing loss. More than 50 affected individuals have been reported worldwide, all Caucasians. We herein identify the first Japanese patient with Susac's syndrome. A 36-year-old man developed recurrent subacute encephalopathy, bilateral sensorineural hearing loss, and retinal arteriolar occlusions, caused by microangiopathy from a year previously. T2-weighted MRI showed multiple high-signal lesions predominantly in the periventricular white matter. During the exacerbated phase both high-dose intravenous methylprednisolone and oral prednisone therapy produced beneficial effects. He showed definite remission within 2 years from the disease onset.
(Internal Medicine 40: 135-139, 2001)
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Shingo TAKATA, Seishi HARADA, Fumihiro MITSUNOBU, Takashi MIFUNE, Yasu ...
2001 年 40 巻 2 号 p.
140-143
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
A 44-year-old man began to experience episodes of joint pain with erythema in his knees, elbows, shoulders, and hands in April 1996. He was diagnosed as having palindromic rheumatism. Due to the increasing frequency and severity of these episodes, he was admitted to our hospital in May 1999. Heat therapy to the affected area produced a rapid improvement in symptoms. In addition, the continued use of physical therapy during symptom-free periods tended to reduce the frequency and severity of pain attacks. We present this case and discuss treatment options in patients with palindromic rheumatism.
(Internal Medicine 40: 140-143, 2001)
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Jitsuo HIGAKI, Tomohiro KATSUYA, Ryuichi MORISHITA, Toshio OGIHARA
2001 年 40 巻 2 号 p.
144-147
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
Under classical strategy, scientists have tried first to find a physiological phenomenon specific for essential hypertension, then to identify the protein underlying the physiological abnormality, and finally to clarify the causative gene which encoded the protein. On the other hand, under the reverse genetic approach, the correlation between hypertension and genetic abnormality is identified first, and then the pathogenesis is clarified-in reverse order. Therefore, it is not extraordinary for unexpected results to be obtained in the correlation between a gene and a disease, suggesting that this approach has a possibility to be a breakthrough in the chaos of hypertension research.
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Hiroki KURIHARA
2001 年 40 巻 2 号 p.
147-151
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Shuichi TAKISHITA
2001 年 40 巻 2 号 p.
151-153
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Koichi HAYASHI
2001 年 40 巻 2 号 p.
153-156
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Toshiro FUJITA
2001 年 40 巻 2 号 p.
156-158
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Shosaku ABE, Hiroki TAKAHASHI
2001 年 40 巻 2 号 p.
159-162
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Ken OHTA
2001 年 40 巻 2 号 p.
162-164
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Yasuyuki YOSHIZAWA, Tadashi FURUIE, Yoshio OTANI, Yuki SUMI, Megumi SA ...
2001 年 40 巻 2 号 p.
164-167
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Saburo SONE, Tsutomu SHINOHARA, Yasuhiko NISHIOKA, Seiji YANO
2001 年 40 巻 2 号 p.
167-170
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Atsushi SAITO, Kazuyoshi KAWAKAMI, Futoshi HIGA
2001 年 40 巻 2 号 p.
171-172
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Kazuhiko KOIKE
2001 年 40 巻 2 号 p.
173-175
発行日: 2001年
公開日: 2006/03/27
ジャーナル
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Satoshi MOCHIDA, Kenji FUJIWARA
2001 年 40 巻 2 号 p.
175-177
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Tetsuya ISHIKAWA, Shinichi KAKUMU
2001 年 40 巻 2 号 p.
178-179
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Norio HAYASHI
2001 年 40 巻 2 号 p.
180-181
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Akira MATSUMORI
2001 年 40 巻 2 号 p.
182-184
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー
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Michio SATA, Yumiko NAGAO
2001 年 40 巻 2 号 p.
185-189
発行日: 2001年
公開日: 2006/03/27
ジャーナル
フリー