抄録
The present study is concerned with the renal function in diabetes mellitus which recently has begun to call special clinical attentions.
1) Among 61 diabetic patients, 15 showed albuminuria, and 27 cases were hypertensives.
2) Excretory rate of P. S. P. showed values in 2/3 and decreased in 1/3 of diabetes. In general, the decreases were seen in the patients with albuminuria, eye findings and hypertension, while a number of cases with hypertension displayed normal rate.
3) GFR and RPF were normal in diabetes without albuminuria, hypertension or eye findings, but decreases in the majority of cases with albuminuria of eye findings. In diabetes associated with hypertension, GFR and RPF were normal in a half of cases and decreases in another half. FF showed definite tendency in its change. Thus it is suggested that the hypertension in diabetes is not of unique origin.
4) The renal hemodynamic in alloxan-diabetic dogs were investigated in order to study the pathogenesis of diabetic nephropathy. In series of experiments, in which 50mg/kg of alloxan were administered, hyperglycemia and glycosuria occurred after 5-7 days, but GFR, RPF and N. P. N. remained normal. In another series with 75mg/kg of alloxan. GFR and RPF showed reduction of 40-90%, marked glycosuria and hyperglycemia were followed by uremia. The blood sugar lavel was proportional to the dose of alloxan. GFR and RPF decreased and histologic renal finding were severe.
