The present study is concerned with the renal function in diabetes mellitus which recently has begun to call special clinical attentions.
1) Among 61 diabetic patients, 15 showed albuminuria, and 27 cases were hypertensives.
2) Excretory rate of P. S. P. showed values in 2/3 and decreased in 1/3 of diabetes. In general, the decreases were seen in the patients with albuminuria, eye findings and hypertension, while a number of cases with hypertension displayed normal rate.
3) GFR and RPF were normal in diabetes without albuminuria, hypertension or eye findings, but decreases in the majority of cases with albuminuria of eye findings. In diabetes associated with hypertension, GFR and RPF were normal in a half of cases and decreases in another half. FF showed definite tendency in its change. Thus it is suggested that the hypertension in diabetes is not of unique origin.
4) The renal hemodynamic in alloxan-diabetic dogs were investigated in order to study the pathogenesis of diabetic nephropathy. In series of experiments, in which 50mg/kg of alloxan were administered, hyperglycemia and glycosuria occurred after 5-7 days, but GFR, RPF and N. P. N. remained normal. In another series with 75mg/kg of alloxan. GFR and RPF showed reduction of 40-90%, marked glycosuria and hyperglycemia were followed by uremia. The blood sugar lavel was proportional to the dose of alloxan. GFR and RPF decreased and histologic renal finding were severe.

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1) Healing in dogs improved with longer duration after treatment.
2) Calcium hydroxide paste showed the best healing, triozinc paste followed, while guttapercha produced poorest results.
3) It was generally observed that the tissue reaction of the periapical structures in human teeth was more inactive than in dogs and the reaction appeared later in the human teeth.

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Thirty-three patients with far-advanced pulmonary tuberculosis were followed for a long period of time. These patients had been given systematic chemotherapy and were considered to be non-surgical candidates, since their sputum remained positive for tubercle bacillus and their cavities and pulmonary function did not show favorable progress. Antituberculous drugs (PZM, INH, IHMS, etc) were administered intracavifarily to this group of patients and the results are as follows.
Comparison between percutaneous and transbronchial administration showed that the former was more effective and safer. The percutaneous method produced less hemoptisis and extention of infiltrates.
4) Changes of cavities
The intracavitary administration was effective in cases with sclerotic cavities.
5) Drug-resistance
Almost all cases were drug-resistant, however, this dia not produce any unfavorable influence on the improvement of cavities.
6) Transbronchial administration
Drugs could be administrated transbronchially with relative ease in patients with sclerotic cavities and expanded draining-bronchi.
7) Improvement of subjective symptoms
No improvement in subjective symptoms was noted.
In summary, the intracavitary administration of antituberculous drugs in patients with far-advanced pulmonary tuberculosis is a procedure which is technically difficult and of limited value. However, this procedure is deemed to be effective in cases with pulmonary tuberculosis which have been by systemic chemotherapy for long periods of time, have become drug-resistant, and are considered to be non-surgical candidates.

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Section I
Since 1953 applying Carlens catheter and Sanborn's respirometer, the author performed measurement test of broncho-lung's containing capacity on 6 healthy adult males. The results obtained are as follows.
1) The average total lung capacity on the right was 2, 260cc, 2, 155cc for the left lung, and the percentage of the total for both sides was 51.2% for the right lung and 48.8% for the left.
2) The rest situations of both lungs in the area of quantitative and qualitative functions were as follows. (Number in perenthesis indicates percentage of the total)
These figures indicate that the function of both lungs presumed to be identical and inductively and statistically no significant differences were noted.
3) The average total lung capacity was 4, 415cc and showed 9.8% decrease in supine position.
4) The measuring method of bronchial lung's capacity is a simple and safe method to measure pulmonary function.
Section II
In order to determine the correlation between chest X-ray findings and pulmonary function of patients with pulmonary tuberculosis, the measurement of bronchial lung's containing capacity was carried out. And results are 's follows.
1) Percentage of affected lung's vital capacity in unilateral focus group was 44.7% in right lung focus group and 40.9% in left lung focus group, indicating no particular difference of lung function between right and left lungs.
2) Lung capacity parallels oxygen intake among patients with parenchymatous focus. And in fresh focus in spite of noticeable X-ray findings the decrease of lung capacity remained slight, while in sclerosed old focus considerable decrease of lung capacity was noted.
3) In patients with bilateral diseases the roentgenographic location of involvement had no effect on function.
4) In the group with pleural involement the decrease of oxygen intake is slight in comparison with the decrease of lung capacity. The location and degree of pleural reaction has a noticeable effect on pulmonary function.
5) Pulmonary function is maintained in artificial pneumothorax of short duration. However, if collapse is prolonged, it will have an unfavorable effect on function.
6) In the group of artificial pneurnoperitoneum, no unfavorable effect on pulmonary function can be demonstrated.

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Eleven male guinea-pigs were infected with tuberculosis by means of intra-cerebral inoculation of the meningies and their encephalogram, clinical course, prognosis, surviving days, body weight change, tuberculin reaction, quantitative bacillary culture, and pathologic findings were studied closely. The results ars as follows.1) The occured abnormal encephalogram is mainly high amplitude slow wave. Depend upon the amount of standard wave (n) and slow wave, the abnormal E. E. G. is classified into I, II, and III types. Besides, some 4-6 c/s, 300-50 spindle shaped high amplitude wave (sp) and cramped wave (cw) can be found.
2) The abnormal E. E. G, appeard prior to clinical symptoms and its appearance rate coincides with the development of parceptable symptoms. The prognosis of the experimental animals can be anticipated by their type of E. E. G.; II and III types or sp is associated with a poor clinical course, while cw is associated with the most unfavorable outcome.3) The E. E. G. changes coincide with body weight increase, but the surviving days do not necessarily correspond with the E. E. G. The positive tuberculin reaction becomes negative and E. E. G, changes unfavorably prior to death.
4) E. E. G. changes at the time of death coincide with the quantitative bacillary culture and pathologic findings.

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1) Many cases showed decrease in the number of erythrocytes, the degree of change was high in normal persons and patients with minimal disease.
2) Hemoglobin content increased in half of the case and decreased in the other half. The red blood cell count corresponds with the hemoglobin.
3) The total white blood cell count were generally increased to some extent, which was thought to be the neutrophilia.
4) in general, a marked neutrophilia was observed which was prominent in cases of minimal symptoms There was, however, a dissociation between the segmented nuclear and band cells. The segmented nuclear cells increased markedly in normal persons and patients with minimal disease, while in moderate or severe cases both types of cells increased to a similar degree.
5) The degree of eosinopenia was inversly proportional to the severity of disease.

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Out of 245 patients with influenza symptom-complex who visited policlinic of the lwate National Sanatorium, 105 patients with PAP syndrome were found during December 1956 and June 1957. 102 out of 105 patients were improperly diagnosed initially as of having pulmonary tuberculosis.
Of these group 31.3% were begun on anti-tuberculoss therapy. Care must be taken in order that the proper diagnosis be made.

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