Recently, a conception of biochelnical modulation, which increases the effect of anti-tumor agents, has been used for cancer chemotherapy. However, there are still few reports that the biochemical modulation was introduced into cancer chemotherapy in the oral region.Therefore, we administered radiotherapy and multi-drug chemotherapy with CDDP, 5-FU/ leucovorin (PFL) to 7 patients who had advanced cancers in the oral region as a preoperative therapy. Clinical therapeutic effects were 2 CR, 3PR and 2 NC; the responsive rate was 71.4%. The histopathological therapeutic effects were 3 G.IV, 2G.Ⅲ and 2 G.Ⅱb; the responsive rate was 100%. The fatal side effects of PFL chemotherapy with irradiation were not observed, but stomatitis accompanied with erosion or ulcers occurred in all cases. From these results, the colnbination of PFL chemotherapy and irradiation was excellent in effects as a preoperative therapy for oral cancers. However, the combination therapy made stomatitis more severe than in each single therapy. In order to decrease the side effects, we need to take care for the time schedule or the dosage of giving anti-tumor agents and irradiation.
