Antitumor Effect of Trehalose on Sarcoma 180 in ICR Mice

Abstract

An antitumor activity on oral administration of trehalose was investigated by using ICR mice implanted Sarcoma 180. After implanting of Sarcoma 180, five kinds of saline solutions containing trehalose (10 to 250 mg/kg) were administrated to mice daily for 10 days. The antitumor effect of trehalose was evaluated by measuring tumor sizes for 3 weeks and tumor weights on week 3. Approximately 70% inhibition ratio was observed in the tested groups admistered a dose higher than dose of 25 mg/kg.