An α2,3-Linked Sialylglycopolymer as a Multivalent Glycoligand Against Avian and Human Influenza Viruses α2,3-Linked Sialylglycopolymer

Tomonari Tanaka; Yiting Zhou; Chihiro Tamoto; Yuuki Kurebayashi; Tadanobu Takahashi; Takashi Suzuki

doi:10.5458/jag.jag.JAG-2017_003

Note

An α2,3-Linked Sialylglycopolymer as a Multivalent Glycoligand Against Avian and Human Influenza Viruses

α2,3-Linked Sialylglycopolymer

Tomonari Tanaka , Yiting Zhou, Chihiro Tamoto, Yuuki Kurebayashi, Tadanobu Takahashi, Takashi Suzuki

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Keywords: sialyloligosaccharide, protecting-group-free, click chemistry, RAFT polymerization, glycocluster effect, influenza virus

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2017 Volume 64 Issue 2 Pages 43-48

DOI https://doi.org/10.5458/jag.jag.JAG-2017_003

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Abstract

A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition. The prepared glycopolymer with pendant 3´-sialyllactose moieties strongly interacted with both avian and human influenza viruses analyzed by the hemagglutination inhibition assay and the quartz crystal microbalance method.

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