2016 年 14 巻 2 号 p. 74-82
In recent years, Use of dental implants is becoming more widespread; however, not all patients can receive implant treatment without bone grafting. Bone grafting is frequently performed in implant treatments, and graft materials include autogenous bone, allografts, xenografts, and alloplasts. The healing mechanism of the autogenous bone graft is not well known; therefore, this study examines the healing mechanism surrounding grafted bone, at both cellular and molecular levels, employing tissue derived from transgenic mice expressing red fluorescent protein in vivo to monitor cellular kinetics in situ and to elucidate the healing mechanism. Results of our study suggested that mineralized tissue regeneration was induced by the transplanted bone representing autogenous bone graft but occurred from the margin of the existing bone.