気道・肺疾患におけるProstaglandinsに関する研究

とくに気管支喘息を中心としたProstaglandinsと2, 3の関連因子の検討

抄録

The plasma prostaglandins (PGE, PGF) and PGF_2α major urinary metadolite (PGF_2α-MUM) levels, 105 cases with bronchial astma, 32 cases with various broncho-pulmonary diseases and 30 cases with normal individuals were mesured using radioimmunoassay method. Various relating factors to PGs and bronchial asthma were also investigated.
The following results were obtained:
1. Plasma PGE levels were higher than PGF levels in normal inividuals. PGF_2α-MUM levels at night were higher than that in the day time in normal individuals.(P<0.02).
2. Urine volume per three hours was correlated with PGF_2α-MUM levels per 1 ml of this urine (r=-0.62, P<0.001), and PGF_2α-MUM levels at night were higher than that in the day time in normal individuals (P<0.02).
3. Plasma PGF levels (P<0.01), PGF/E raito (P<0.01) and PGF_2α-MUM levels (P<0.001) in the patients with asthmatic attack were higher than those in the attack free individuals, pulmonary tubercurosis and normal controls, but there were no significant correlationship among the patients with lung cancer, bronchiektasis and pulmonary fibrosis. PGF2a-MUM levels in the status asthmaticus were increased significantly.
4. Plasma PGF levels were correlated with PGF_2α-MUM levels in the patients with bronchial asthma (r=0.67, P<0.001).
5. The change of PGF_2α-MUM levels in atopic asthma were severe than in non atopic asthma, however, specific relation could not be found between the PGs levels and other factors such as eosinophilus, basophilus, serum IgE levels and type of asthma.