気道, 肺疾患の免疫遺伝学的研究

とくに気管支喘息を中心としたHLA抗原と2.3の関連因子との検討

抄録

Phenotype frequencies and haplotype of HLA antigens in 297 cases with various bronchopulmonary diseases were studied using the method of lymphocyte microcytotoxicity test. The following results were obtained.
1. High frequencies of HLA-A2, HLA-A9, HLA-B5, HLA-BW40 were recognized in normal individuals.
2. HLA-BW21 in the patients with chronic bronchitis was higher than those in normal individuals (P<0.05). However, there were no differences of frequencies of HLA antigens in chronic pulmonary emphysema, pulmonary tuberculosis, lung cancer, pulmonary sarcoidosis, cystic fibrosis, bronchiectasis, pneumoconiosis, pulmonary alveolar microlithiasis and normal individuals.
3. Frequencies of HLA-BW38 in the patient with nasal allergy and frequencies of HLA-BW40 in the patient with bronchial asthma were higher than those in normal individuals (P<0.05). In those various factors, high serum IgE levels and high IgE antibody titers showed to be corelated to HLA-BW40.
4. We can not prove asscciated haplotype in atopic families. The other hand, relationship between haplotype HLA-A10, B12 and onset of the disease were suggestted in family study of the patient with hypersensitivity pneumonitis.
5. High phenotype frequencies of HLA-B5 were recognized in acute myelocyte leukemia (P<0.05). HLA-B27 was detected in all patients of ankylosing spondylitis.