総合健診
Online ISSN : 1884-4103
Print ISSN : 1347-0086
ISSN-L : 1347-0086
Original Articles
Indicator of arteriosclerosis in patients with COPD
Akinori EBIHARAAkifumi WATANABEAsuka NAGAIRurika HAMANAKANaoko IMAMURAChizumi YAMADATokuzen IWAMOTOIchiro KUWAHIRA
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ジャーナル オープンアクセス

2014 年 41 巻 4 号 p. 528-532

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Background Cardiovascular events are important comorbidities and complications of chronic obstructive pulmonary disease (COPD). We analyzed data on the maximum intima media thickness (max-IMT), the ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA), and the Ankle Brachial Pressure Index (ABI) to determine whether there are any correlations among these parameters.
Methods A total of 149 subjects (84 men, 65 women) were enrolled in the study between May, 2007 and January, 2014 at the Erimo town clinic in Hokkaido after providing their informed consent. Potential subjects were divided into two groups: Group 1 (G1) had a history of COPD and moderate to severe exposure to tobacco smoke, and a Brinkman Index>400; Group 2 (G2) had a history of other diseases without COPD, such as diabetes, hypertension, and hyperlipidemia.
Results G1 included 73 subjects (47 men, 26 women) and G2 included 76 subjects (37 men, 39 women). The max-IMT was1.49±0.83 mm for G1 and 1.36±0.68 mm for G2, the ABI values were 0.81±0.48 and 0.91±0.21, and the EPA/AA values 0.41±0.13 and 0.47±0.16, respectively. The Max-IMT of G1 was thus significantly larger than that of G2, and the ABI of G1 was significantly lower than that of G2. There was no significant difference in EPA/AA between G1 and G2.
Conclusion In COPD patients with moderate to severe exposure to smoke, a significant increase in max-IMT and decrease in ABI were observed. The results of the present study suggest that COPD patients are at increased risk of smoke-related cardiovascular diseases such as acute myocardial infarction and stroke. However, the EPA/AA ratio might not be a good biomarker for assessing cardiovascular risks in COPD.

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© 2014 Japan Society of Health Evaluation and Promotion
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