2016 年 43 巻 4 号 p. 518-524
Objective. The purpose of the study was to determine the distribution of estimated glomerular filtration rate (eGFR) values among the Japanese working generation using representative health checkup data.
Design. Cross-sectional, observational, large cohort study
Setting. Japan Health Insurance Association, Tokyo Branch
Participants. Data for 766,556 participants aged 35-74 years who attended preventative health checkup for lifestyle-related disease conducted by the Japan Health Insurance Association, Tokyo Branch, in 2012 were included. After excluding dialysis patients and those with missing data, 766,095 participants (mean age, 48.9 years; 68.1% male) were selected for analysis.
Main outcome measures. Serum creatinine-based eGFR values were analyzed in 5-year age groups.
Results. The age-specific mean eGFR values were 86.4, 83.0, 79.8, 77.4, 75.5, 73.2, 70.9, and 67.8 mL/min/1.73 m2 for the age groups of 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, and 70-74 years, respectively. The difference in eGFR per 1-year difference in age was 0.523 mL/min/1.73 m2/year. The mean eGFR was higher in the female participants for all age groups, being most apparent in those aged 35-50 and 60-74 years. However, without body surface-area correction, the mean eGFR was lower in the female participants for all age groups.
Conclusion We described the distribution of eGFR values on the basis of a large data set obtained during health checkup examinations in Japan. We found these data to be representative of the 35-74 year-old Japanese general population.
