抄録
The aim of the present study was to investigate the relationship among the clinical and laboratory signs in response to insulin resistance evaluated by a homeostasis model (HOMA-IR) in Japanese non-obbbbese men working abroad. A significantly positive correlation was observed between body mass index (BMI) and HOMA-IR values in the normal weight (r=0.34; p<0.0001) and the obese group (r=0.52; p<0.0001), but not in the lean group (r=0.16; p=0.28) . There was a significantly positive correlation between fasting plasma glucose values and HOMA-IR in three groups. Plasma alanine transferase (ALT), γ-glutamyltranspeptidase (γ-GPT) and Cholinesterase (Ch-E) values were significantly lower in the lean group than those in other groups; ALT: 18.7, 24.2, 42.3 IU/l; γ-GTP: 36.0, 51.0, 74.3 IU/l; Ch-E: 268, 310, 353 IU/l, respectively. There was a significantly positive correlation between HOMA-IR and plasma ALT or Ch-E values in three groups, but other liver functions values were not correlated with HOMA-IR in three groups. These data indicated that insulin resistance was present in almost all men with fatty liver, and insulin resistance was never associated with obesity, hyperdyslipemia in the non-obese men, and the mechanism for underlying insulin resistance in the non-obese men might be different from that in the obese men.
