Health Promotion and Genome in Japanese

抄録

Current health promotion is based on average evaluations obtained from statistics of large populations but, in reality, the range of 2SD (standard deviation) may not cover medical and nutritional requirements owing to genetic polymorphisms among healthy individuals. Thus, nutrigenomics in human energy metabolism is needed for personalized health promotion based on individual genetic evaluation of single nucleotide polymorphisms (SNPs) etc. Energy metabolism depends on thrifty genes including SNPs of transporters (uncoupling proteins etc.) and receptors (adrenergic receptors etc.) . The impact of Westernization on both nutrition and thrifty genes of Japanese has caused a rapid increase in metabolic syndrome. In health promotion, personality is also important in behavioral change; most Japanese have the obedient S/S genotype of the serotonin transporter gene, and careful instruction is needed in health promotion. Our personalized health promotion program reversed metabolic syndrome, not only in the short-term (11 months), but also in the long-term (average, 23 years) irrespective of the presence of thrifty genes. However, the rapid increase in metabolic syndrome will need more advanced omics of adipose tissue, including those of prohibitin and resveratrol. The prevention of final disability resulting from cardiovascular diseases and dementia is important. In addition to thrifty genes, we should consider methylene tetrahydrofolate reductase SNP in C677T. To prevent hyperhomocysteinemia, improvement of serum folate was easier when genome information was given to examinees.