Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RESEARCH LETTERS
Genetic Evidence of Resistance to Cadmium Toxicity in Wistar-Imamichi Rats
Hideaki ShimadaYasutaka TakamureYorishige Imamura
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2003 Volume 49 Issue 4 Pages 316-318

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Abstract

Resistance to the toxicity of cadmium (Cd) was examined in male Wistar-Imamichi (Wistar-IM) and Fischer 344 (Fischer) rats. The Wistar-IM strain was confirmed to exhibit strong resistance compared to the Fischer strain. The resistance in first filial (F1) males was intermediate between that in Wistar-IM and that in Fischer males. The data from reciprocal crosses indicate that the strong resistance to Cd toxicity in male Wistar-IM rats is autosomal and inherited as an incompletely dominant phenotype.

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© 2003 by The Pharmaceutical Society of Japan
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