MRP5b/SMRP mRNA is Highly Expressed in Metallothionein- Deficient Mouse Liver

Toshihiro Suzuki; Mika Agui; Tadayasu Togawa; Akira Naganuma; Kazuto Nishio; Shinzo Tanabe

doi:10.1248/jhs.49.524

Journal of Health Science

Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702

RESEARCH LETTERS

MRP5b/SMRP mRNA is Highly Expressed in Metallothionein- Deficient Mouse Liver

Toshihiro Suzuki, Mika Agui, Tadayasu Togawa, Akira Naganuma, Kazuto Nishio, Shinzo Tanabe

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Keywords: metallothionein, multidrug resistance protein, multidrug resistance protein 5

JOURNAL FREE ACCESS

2003 Volume 49 Issue 6 Pages 524-526

DOI https://doi.org/10.1248/jhs.49.524

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Abstract

To investigate whether multidrug resistance protein 5 (MRP5) functions as a xenobiotic detoxification factor, we measured MRP mRNA expression levels in metallothionein (MT)-I, II knockout mouse, and the results showed that MRP5b/SMRP, a splicing variant of MRP5, was highly expressed in the liver of MT-I, -II null mice.

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