Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
REGULAR ARTICLES
Antinociceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract
Mani VasudevanKumar Kishore GunnamMilind Parle
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2006 Volume 52 Issue 5 Pages 598-606

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Abstract

The ethanolic extract of Daucus carota seeds (DCE) was investigated for anti-inflammatory and analgesic activity at the doses [per oral (p.o.)] of 100, 200 and 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine- and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats. The acetic acid-induced writhing response and formalin-induced paw licking time in the early and late phases of mice were used to assess analgesic activity. The higher doses of DCE (200 and 400 mg/kg, p.o.) were inhibiting carrageenan, histamine and serotonin-induced paw edema as well as formaldehyde-induced arthritis successfully. In addition, DCE (200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and late phase of pain response induced by an subplantar injection of formalin in mice.

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© 2006 by The Pharmaceutical Society of Japan
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