Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the antioxidant properties of Triphala (Terminalia chebula, Terminalia bellerica and Emblica officinalis) during cold-stress. Four groups of albino rats were employed namely control, Triphala, cold-stress and Triphala with cold-stress. The oxidative stress was assessed by measuring the lipid peroxidation (LPO), enzymatic superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymatic (Vitamin C) antioxidant status in adrenal tissue and plasma corticosterone level. Following cold-exposure (8°C for 16 hr/d/15 days), enzymatic and non-enzymatic antioxidants were significantly reduced with concomitant increase in LPO and corticosterone levels were observed. Administration of Triphala (1 g/kg/body weight/48 days) significantly prevents the cold-stress-induced oxidative stress and elevation in LPO and corticosterone levels. This study concludes that Triphala supplementation significantly prevents the cold-stress-induced oxidative stress may due to its antioxidant properties.
2006 by The Pharmaceutical Society of Japan