Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RESEARCH LETTERS
Hypothermia after Reperfusion Suppresses Aggravation of Acute Brain Edema following Transient Forebrain Ischemia in Mice
Masaru DoshiEtsuka HiguchiYutaka Hirashima
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2011 Volume 57 Issue 1 Pages 82-85

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Abstract

In our previous paper, we reported that spontaneous hypothermia (HT) during ischemia protects against delayed neuronal death in the hippocampus but not against acute brain edema following transient forebrain ischemia, which is induced by occlusion of the bilateral common carotid arteries (BCCA) in C57BL/6J mice. We here demonstrate that artificial HT after reperfusion (rHT) suppresses the aggravation of acute brain edema in the BCCA occlusion C57BL/6J mouse model. Our results suggest that mechanisms regulated by rHT are involved in the attenuation of acute brain edema after reperfusion in this model of cerebral ischemia.

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© 2011 by The Pharmaceutical Society of Japan
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