Radiation Sterilization of Drugs. I : Chlorophyll Derivatives (1)

Abstract

The application of radiation to the sterilization of drugs was studied using water soluble chlorophyll derivatives. Copper chlorophyll, methionine cobalt chlorophyll, and 5, 6-dimethyl benzimidazole cobalt chlorophyll, in solid state were irradiated with ⁶⁰Co γ-rays. No detrimental effect on the chemical properties was observed at a dose of 3 Mrad. The sterility test was performed according to the direction in the Japanese Pharmacopoeia, Ed. VII. An adequate dose for the sterilization of chlorophyll derivatives is estimated to be 1∼2 Mrad.