Abstract
Spectrophotometric Determination of acetaminophen in pharmaceutical preparations is described. Acetaminophen was hydrolysed by refluxing with perchloric acid to produce p-aminophenol which was reacted with p-dimethyl aminocinnamaldehyde in dilute trichloracetic acid solution to give a red color, which showed absorption maximum at 520 nm. Interference by the presence of phenacetin and sulpyrine can be eliminated by their extraction with chloroform in basic medium or extraction with ethyl acetate in acidic medium.
