Studies on the Antioxidants. VII. The Formation of Butyl Hydroxyanisole (BHA) Oxidation Product in the Rat and Rabbit

Abstract

Experiments were carried out to find possible in vivo formation of the oxidation products from butyl hydroxyanisole (BHA), which were confirmed to be formed by light irradiation of BHA. Diphenyl compound, essentially the same as those found in the air, were recovered from the urine of rabbits and rats treated with BHA. In studies on metabolization of these oxidation products, unchanged 2-BHA was detected in the urine. It was thereby confirmed that the reversible reaction of BHA to the diphenyl compound, and vice versa, actually occur in vivo.