Abstract
Cadmium chloride solution was administrated intraperitoneally in a dose of 1 mg/kg body weight to rats, and the behavior of uptake of cadmium into femur was examined, with the following results. 1) Uptake of cadmium into the bone was higher in metaphyseal bone than in diaphyseal bone. Three weeks after administration, uptake of cadmium into the metaphyseal bone became about 7-8 times that in the diaphyseal bone. 2) Uptake of cadmium into diaphyseal and metaphyseal bones tended to become higher in proportion to the aging of animals, but there was no significant corelation between that and sex and age of the animals. 3) In animals fed a low calcium diet and high phosphorus diet, uptake of cadmium into the bone was significantly higher than in animals fed a normal diet. This result suggested that uptake of cadmium into the bone was closely related to the mobilization of calcium in the bone (bone resorption). 4) The uptake of cadmium into the diaphyseal and metaphyseal bones was similar to that of lead and strontium.
