1983 Volume 29 Issue 5 Pages 286-291
The accumulation amounts of 5 aniline derivatives in killifish, gold fish and carp were determined in connection with their syncopic effect. In the case of aniline and o-toluidine, their amounts in fish increased proportionally to the concentration of the compounds in test solution, and the amounts gradually increased after the death of fish. On the contrary, the amounts stayed at constant level and syncopic states were observed for 48 h when 2, 6-xylidine, N-methyl aniline and N, N-dimethyl aniline were used, indicating the presence of threshold. Partition coefficient of aniline derivatives between n-octanol and water corresponded obviously to the amount of the compounds accumulated in fish body, but the relationship between partition coefficient and LC50 or SC50 values was not observed. It was considered from these results that syncopic state of fish may be a kind of selfguard action to prevent the accumulation of toxic compounds into their body.
