1988 Volume 34 Issue 6 Pages 495-500
Contaminant (s) in sodium chondroitin sulfate (SCS) preparations can strongly accelerate formation of nitrosamines from secondary amines and nitrite. About 70% of nitrosation-accelerating activity (NAA) was recovered in the filtrate through a DIAFLO YC 05 ultrafiltration membrane. The results of ultrafiltration and column chromatography using Sephadex G-10 identified that the molecular weight of the main component that showed NAA was several hundreds. It reacted with nitrite and gradually lost its NAA. It did not accelerate formation of nitrosomethylurea. It accelerated formation of nitrosodimethylamine additively with thiocyanate, a well known accelerator of nitrosamine formation.
