Abstract
Commercial Food Yellow No.5 showed genotoxic activity in Drosophila wing spot test. Seventy-two hours larvae of Drosophila were treated chronically (during the whole third larval instar) with commercial Food Yellow No.5. The frequencies of single spots increased 4-fold that of control. Commercial Food Yellow No.5 involved some impurities. Impurity fraction A, which contained more polar compounds than Food Yellow No.5, showed DNA damage in Drosophila DNA-repair test. These results suggested that the impurities would be contributed to the genotoxicity of commercial Food Yellow No.5.
