Comparison of the In Vitro Antifungal Activities of Ketoconazole and Griseofulvin Against Clinical Isolates of Dermatophytes

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Ketoconazole, a new imidazole derivative, and griseofulvin, are the two most valuable oral antimycotics for oral administration in the treatment of dermatophytosis. The antifungal properties of ketoconazole were compared in vitro with those of griseofulvin using a liquid microculture method and 68 clinical isolates of dermatophytes. Both drugs showed minimal inhibitory concentration (MIC) values of ≤5μg/ml for all isolates of Trichophyton rubrum. The MIC values of griseofulvin for 90% of Trichophyton mentagrophytes isolates ranged from 0.5 to 3μg/ml; the MIC values of ketoconazole for Trichophyton mentagrophytes ranged from 0.5 to 5μg/ml or greater. Microsporum species were 2.3-6.3 times more susceptible to griseofulvin than to ketoconazole; Epidermophyton floccosum was uniquely susceptible to both drugs.