Effects of Histidine on Working Memory Deficits Induced by the 5-HT1A-Receptor Agonist 8-OH-DPAT

Shinji Isayama; Yukio Sugimoto; Miyuki Nishiga; Chiaki Kamei

doi:10.1254/jjp.86.451

Short Communications

Effects of Histidine on Working Memory Deficits Induced by the 5-HT_1A-Receptor Agonist 8-OH-DPAT

Shinji Isayama, Yukio Sugimoto, Miyuki Nishiga, Chiaki Kamei

著者情報

キーワード: Histidine, 8-Hydroxy-2-(di-n-propylamino)tetralin, Radial maze performance

ジャーナルフリー

2001 年 86 巻 4 号 p. 451-453

DOI https://doi.org/10.1254/jjp.86.451

詳細

抄録

We investigated the effects of histidine on spatial memory deficits induced by the 5-HT_1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

責任著者(Corresponding author)

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