アスコルビン酸の輸液中での安定性 (II)

オーツカMV注およびマルタミン混注後の過酸化水素の生成および金属の影響

抄録

In our previous report, we showed that producing hydrogen peroxide increased on standing in infusion solution to which was added multivitamins. Likewise, producing hydrogen peroxide increased on standing after mixing, increasing to 6.76 ppm with the combination of KN solution MG3 with Otsuka MV and to 6.65 ppm with the combination of Solita T^®-4 with Multamin^®. The Zn²⁺ and Mn²⁺ metal ions showed a little effect on the degradation of ascorbic acid (AsA) in spite of the shield, whereas Cu²⁺ remarkably promoted AsA degradation.