The total IgE level and the specific of IgE, G, A, M class antibodies against Aspergillus fumigatus were measured in the sera of six patients with ABPA by the methods of RIST, RAST, double antibody technique and Protein A-Sepharose CL-4B particles. The results were compared with the clinical courses. The summary of the discussion and conclusion is as follows;
1) In the active phase, the total IgE levels and the titer of specific anti-Asp. antibodies in each class in the sera of patients were higher than in the inactive phase. In the inactive phase, these levels decreased within normal ranges in some patients.
2) These levels and titers tended to increase before the clinical findings of exacerbation appeared Therefore they could be used as indices of exacerbation beforehand.
3) They increased from winter to late spring. Thus our data suggest that ABPA may get worse in that season.
4) Adrenocorticosteroid hormone was effective to reduce the titer of specific anti-Asp. antibodies. The inhalation of amphotericin B was effective to treat ABPA in some patients.
