短報
PAX8 免疫染色が診断に有用であった Napsin A 陽性甲状腺癌による癌性胸膜炎の 1 例
2016 年 55 巻 5 号 p. 355-356
詳細
2016 年 55 巻 5 号 p. 355-356
We report the case of a 67-year-old male patient who presented with multiple pulmonary nodules and right pleural effusion 7 years after undergoing thyroidectomy for papillary carcinoma.
The effusion contained clusters of atypical cells which were immunocytochemically positive for Napsin A, as well as for TTF-1 and PAX-8. Re-evaluation of the primary thyroid carcinoma revealed Napsin A positivity in the cancer cells with focal squamous differentiation.
Napsin A is a useful marker of pulmonary adenocarcinoma ; however, caution is needed since some carcinomas in other organs could also express this marker. PAX-8 staining is useful to differentiate carcinomatous pleuritis secondary to Napsin A-positive thyroid carcinoma from that secondary to pulmonary adenocarcinoma.
