A case of prostatic ductal adenocarcinoma demonstrated in the bladder washing fluid specimen prompted us to write a case report.
An 80-year-old man presented with gross hematuria. Cytological examination of bladder wash specimens revealed tight aggregates of tall columnar cells showing a papillary structure, peripheral nuclear palisading, and glandular formation. The neoplastic cells had large round-to-oval nuclei containing conspicuous nucleoli and vesicular chromatin. Immunocytochemically, the tumor cells showed positive staining for PSA.
Prostatic ductal adenocarcinoma must be included in the differential diagnosis when atypical tall columnar cells are detected in urine/bladder wash specimens. The combination of the cytological features and positive immunocytochemical staining for PSA helps in the differential diagnosis.
