抄録
The presence of NES and S-100 protein was investigated immunohistochemically using paraffin sections of surgically resected tumor tissues of 31 neuroblastoma group tumors in children. The tumors studied consisted of 26 neuroblastomas, 4 ganglioneuroblastomas and 1 ganglioneuroma. Malignant Schwannoma, Wilms' tumor, hepatoblastoma and rhabdomyosarcoma were also examined to compare with neuroblastoma tumors. NSE was detected in 30 of 31 neuroblastoma group tumors and 31 neurs Hastoma group in out of rhabdomyosarcoma. Som ganglion-like cells appearing in the ganglioneuroblastoma and ganglioma were atained strongly with anti-NSE but others were negative. 4 ganglioneuroblastoma and 1 ganglioneuroma were positive for S-100 protein and all other kind of tumors investigated were negative. In tissues of the ganglioneuroblastoma ane ganglioneuroma, Schwann cells and the satellite cells of the ganglion were stained strongly. It is concluded that NSE stain is a reliable method for distinguishing neuroblastoma fram other non-neuronal round cell tumors in children, and that there was a good correlation between the intensity of NSE stain and histological differentiation of the neuroblastoma group tumors. If was conduded also that the fumor wite positive cells for S-100 protein have a good prognosis.
