抄録
Detection of each fragment of FDP, especially D-dimer (D-D), is an important step for the defferentiation of in vivo fibrinolytic activity, whether it is the primary step or the secondary one. In this report, a method for the detection of these fragments was investigated. The defibrinated plasma was treated with immunoabsorbance affinity chromatography, and then with SDS-polyacrylamide gel electrophoresis. The electrophoretic pattern showed good separation of the fragments X, Y, D, E and D-D. Relative amount of D-D fragment against D fragment was designated as RD-D(Area D-D/Area D×100).
D-D fragment was detected on the electrophoretic pattern not only in the cases of DIC, but also in many diseases including renal failure, malignant tumors and blood diseases. Good correlation was observed between RD-D and FDP (assayed by immunonephrometry) in the cases of acute DIC, but not in other diseases.
