抄録
The action of phenol on the central nervous system which is known to increase in the blood and the spinal fluid at the time of hepatic disturbances was studied on the rabbits.
1. The arousal reaction and muscular discharge due to a stimulation given to the thalamus and reticular formation were stimulated by administration of a small dose of phenol, while they were inhibited by a large dose of phenol. The same results were obtained as to the recruiting response and the spike and wave complex.
2. As the dose of phenol was increased, the frequency of the spontaneous brain wave tended to slow down, and also 4-5 c/s waves and triphasic wave became conspicuous. The spontaneous muscular discharge in the fore and hindlimbs tended to increase gradually as the dose of phenol was increased. These stimulating effects were observed even when the triphasic wave appeared.
3. The histologic al changes in the liver by phenol administration were those remniscent of an acute hepatic insufficiency.
From these results, it will be concluded that phenol inhibits the consciousness by the inhibitory action on the ascending activating system and stimulates the motion by the action on the extrapyramidal system.
Furthermore the comparativ e study was done between the administration of phenol and the ligation of the common bile duct. Phenol seems to be one of the factors which influences the symptoms occurring in the ligation of the common bile duct.
