脂質栄養学
Online ISSN : 1883-2237
Print ISSN : 1343-4594
総説
食事由来腸内細菌代謝産物、短鎖脂肪酸と宿主代謝制御
木村 郁夫畑野 泰子長谷川 沙恵
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ジャーナル フリー

2015 年 24 巻 1 号 p. 33-40

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Gut microbiota affects not only host immune system but also host nutrient acquisition and energy regulation, and thereby influencing the development of obesity and diabetes. Short-chain fatty acids (SCFAs), produced by the gut microbial fermentation of dietary fiber, are essential host energy sources and signal molecules via G-protein coupled receptor GPR41 and GPR43. We report that these SCFAs receptors are involved in host energy homeostasis, GPR41 regulates sympathetic activity, and GPR43 regulates adipose-insulin signaling by sensing SCFAs. These results indicate that gut microbial metabolites regulate host homeostasis via novel molecular signal mechanism.

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© 2015 日本脂質栄養学会
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