ホスファチジルイノシトール50（PI 50）の摂取によるラットの 記憶・学習能力増強とホスファチジルイノシトールの関係について

抄録

Objective: Phosphatidylinositol 50（ PI 50） intake has been shown to stimulate neuronal activation and nerve cell proliferation, which may enhance learning and memory ability in rats. In the present study, we aimed to clarify whether these effects of PI 50 are due to phosphatidylinositol（ PI） by using treatments of PI-degraded preparations compared with PI 50 in a rat model. Methods: Male Wistar rats were divided into（1） distilled water,（2） PI 50, and（3） PI degraded preparation administration groups. The effects of oral administration of PI 50 or a PI-degraded preparation on memory and learning ability in rats were investigated using behavioral and molecular biological techniques. Results: We found that the group administered with PI 50 showed improvements in spatial memory, and learning ability, as well as increased c-Fos- and BrdU-positive cells in the hippocampus, and showed a significant increase in BDNF, PKC- α , and MAPK protein expression compared to the group administered with distilled water. However, these effects were not confirmed in the PI-degraded preparation administration group. Conclusion: The results suggested that learning ability and memory in rats were enhanced by PI 50 administration, which may be due to the action of the PI within PI 50. In the future, it will be necessary to study the preventive and ameliorating effects of PI 50 in cognitive diseases.