Juntendo Medical Journal
Online ISSN : 2188-2126
Print ISSN : 2187-9737
ISSN-L : 2187-9737
Original Articles
Salivary Chromogranin A as a Psychosomatic Stress Marker Is Suppressed in Laparoscopic Surgery Compared with Open Surgery for Colon Cancer
SHUN ISHIYAMAKAZUHIRO SAKAMOTOHIROHIKO KAMIYAMAKOICHIRO NIWAKIICHI SUGIMOTOMAKOTO TAKAHASHIYUTAKA KOJIMAMICHITOSHI GOTOATSUSHI OKUZAWAYUICHI TOMIKI
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2017 Volume 63 Issue 2 Pages 88-94

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Abstract

Objective: The advantages of laparoscopic surgery have been described in previous studies. The aim of this study was to objectively evaluate the benefits of laparoscopic surgery (LS) vs. conventional open surgery (OS) by measuring stress markers.

Materials: Fifty-four patients who underwent radical resection for primary colon cancer between May 2008 and March 2011 were enrolled. Thirty-two of the 54 patients underwent LS and twenty-two underwent OS.

Methods: Peripheral blood and saliva samples were obtained on five occasions during the perioperative period. Salivary Chromogranin A (CgA), derivatives of Reactive Oxygen Metabolite Test (d-ROMs Test), interleukin 6 (IL-6), natural killer (NK) cell activity and C-reactive protein (CRP) levels were analyzed for comparison between the two groups.

Results: With respect to the clinical characteristics, the intraoperative blood loss was significantly lower, and the operating time was longer in the LS group. Early postoperative oral-intake and reduced postoperative hospitalization were observed in the LS group. The salivary CgA, serum IL-6, and CRP were significantly lower in the LS group compared with the OS group. There was no difference in the d-ROMs finding between the two groups.

Conclusions: In the present study, there were significant differences in postoperative oral in-take, postoperative hospitalization, IL-6, CRP, and salivary CgA, suggesting an advantage of LS for patients with colon cancer. With respect to our finding of perioperative salivary CgA, further studies will be necessary to demonstrate the significance of this interesting and promising test.

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© 2017 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited.
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