THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES OF THIAMINE MONOPHOSPHATE DISULFIDE
能勢 尚志安田 晃三中間 元隆足立 史郎甲和 良夫山田 茂樹石川 節子千畑 一郎
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1966 年 12 巻 1 号 p. 33-41

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Thiamine monophosphate disulfide (TMPDS) exhibited the thiamine action in rats nearly equal to that of thiamine-HCl. After intravenous injection of TMPDS in a dog, the levels of total thiamine and thiamine diphosphate in blood were much higher than after administration of thiamine-HCl, retaining the level for a longer period.
On the other hand, TMPDS trended to retard the urinary excretion and it showed beneficial effects on analgesic action and prevention of fatigue in swimming of mice.
As for the general pharmacological action of TMPDS, it showed qualitatively similar behaviors against respiro-circulatory systems to those of thiamine-HCl. The former lowered the blood pressure more slowly than the latter in rabbits. Administration of TMPDS, 20mg per kg, brought about the tension and acceleration of the movement of the intestine in rabbits in situ similarly to thiamine-HCl. In any case, if the pharmacological action of TMPDS is assumed to be a side effect to vitamin action, it is considered to have only a veryr slightly one.
Acute toxicity in mice was much slighter than that of thiamine-HCl in mice. The compound was found much more resistant to thiaminase I and II than thiamine-HCl.
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