Antifungal effect of Moringa oleifera leaf extract on Candida albicans

抄録

Candida albicans is a common pathogen, especially in immunocompromised patients. What is concerning is that this pathogen is displaying increasing resistance to azole drugs, which are commonly used to treat it. We investigated the antifungal activity of Moringa oleifera leaves against C. albicans. The fungicidal effect of C. albicans exposed to Moringa oleifera leaves was determined using adenosine triphosphate (ATP) bioluminescence. Moringa oleifera leaves showed antifungal activity against C. albicans with a minimum inhibitory concentration (MIC) of 50 μg/mL. Additionally, at the MIC, the Moringa oleifera leaves significantly reduced ATP-leakage. This study provides sufficient evidence of the in vitro antifungal effects of Moringa oleifera leaves against C. albicans. (J Osaka Dent Univ 2023; 57: 295-299)