Journal of Occupational Health
Online ISSN : 1348-9585
Print ISSN : 1341-9145
ISSN-L : 1341-9145
Original Articles
Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men
Mi XiangHuanhuan HuTeppei ImaiAkiko NishiharaNaoko SasakiTakayuki OgasawaraAi HoriTohru NakagawaShuichiro YamamotoToru HondaHiroko OkazakiAkihiko UeharaMakoto YamamotoToshiaki MiyamotoTakeshi KochiMasafumi EguchiTaizo MurakamiMakiko ShimizuKentaro TomitaSatsue NagahamaAkiko NanriMaki KonishiShamima AkterKeisuke KuwaharaIkuko KashinoMiwa YamaguchiIsamu KabeTetsuya MizoueNaoki KunugitaSeitaro Dohithe Japan Epidemiology Collaboration on Occupational Health Study Group
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2020 Volume 62 Issue 1


Objectives: We aimed to compare the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with risk of cardiovascular disease (CVD) among middle-aged working Japanese men.

Methods: A nested case-control study was performed among middle-aged male employees who underwent periodic health checkup. A total of 241 CVD cases were identified and matched individually on age, gender, and worksite with 1205 controls. Data on BMI, WC, WHtR, smoking, hypertension, diabetes, and dyslipidemia collected at 4 years before the event/index date were retrieved. Associations between BMI, WC, WHtR, and CVD risk were assessed by using conditional logistic regression models.

Results: The strength of the association of BMI, WC, and WHtR with CVD risk was similar. The smoking-adjusted odds ratio (95% confidence interval) for CVD was 1.60 (1.38-1.85), 1.53 (1.33-1.78), and 1.56 (1.35-1.81) for a 1 SD unit increase in BMI, WC, and WHtR respectively. After further adjustment for hypertension, diabetes, and dyslipidemia, these associations were attenuated but remained statistically significant.

Conclusions: Measures of general (BMI) and abdominal (WC and WHtR) obesity were similarly associated with CVD in middle-aged Japanese men.

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© 2019 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health

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