Abstract
Therapeutic Efficacy of a Few Diesters of Meso 2, 3-Dimercaptosuccinic Acid during Sub-Chronic Arsenic Intoxication in Rats: S.J.S. FLORA, et al. Division of Pharmacology and Toxicology, Defence Research and Development Establishment—The therapeutic efficacy of four diesters derivatives of meso 2, 3-dimercaptosuccinic acid (DMSA) was investigated in subchronic arsenic intoxication in rats. Dimethyl DMSA (DMDMSA), diethyl DMSA (DEDMSA), diisopropyl DMSA (DiPDMSA) and diisoamyl DMSA (DiADMSA) were the diesters of DMSA with methyl, ethyl, isopropyl and isoamyl alcohols and were administered for two 5 day courses of treatment in male rats pre-exposed to 100 ppm arsenic (III) for 8 weeks. The results show that treatment with these diesters was effective in decreasing blood and soft tissue arsenic contents but was only moderately effective in recovering biochemical indicators. The results suggest that these diesters could be effective arsenic chelators but may be inferior to DMSA in recovering biochemical/clinical indicators following sub-chronic arsenic exposure. (J Occup Health 1997; 39: 119-123)
