Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts

Bruna Borelli; Fernando Zarone; Virginia Rivieccio; Francesco Riccitiello; Michele Simeone; Roberto Sorrentino; Sandro Rengo; Gianrico Spagnuolo; Alfredo Procino

doi:10.2334/josnusd.16-0388

Original

Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts

Bruna Borelli, Fernando Zarone, Virginia Rivieccio, Francesco Riccitiello, Michele Simeone, Roberto Sorrentino, Sandro Rengo, Gianrico Spagnuolo, Alfredo Procino

Author information

Bruna Borelli
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Fernando Zarone
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Virginia Rivieccio
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Francesco Riccitiello
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Michele Simeone
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Roberto Sorrentino
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Sandro Rengo
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Gianrico Spagnuolo
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School
Alfredo Procino
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School

Keywords: inflammation, interleukin-6, cytotoxicity, cell culture, cytokines

JOURNAL FREE ACCESS

2017 Volume 59 Issue 1 Pages 87-91

DOI https://doi.org/10.2334/josnusd.16-0388

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Abstract

Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation.

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