Strigolactones—a novel class of phytohormones as anti-cancer agents

Mohammed Nihal Hasan; Syed S. I. Razvi; Abudukadeer Kuerban; Khadijah Saeed Balamash; Widad M. Al-Bishri; Khalid Omar Abulnaja; Hani Choudhry; Jehan A. Khan; Said Salama Moselhy; Zamzami Ma; Taha A. Kumosani; Abdulrahman L. Al-Malki; Mahmoud Alhosin; Tadao Asami

doi:10.1584/jpestics.D17-090

Reviews

ストリゴラクトン: 抗癌剤としての新しい植物ホルモン

Hasan Mohammed Nihal, Razvi Syed S. I., Kuerban Abudukadeer, Balamash Khadijah Saeed, Al-Bishri Widad M., Abulnaja Khalid Omar, Choudhry Hani, Khan Jehan A., Moselhy Said Salama , M Zamzami, Kumosani Taha A., Al-Malki Abdulrahman L., Alhosin Mahmoud, Asami Tadao

著者情報

Hasan Mohammed Nihal
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Razvi Syed S. I.
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Kuerban Abudukadeer
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Balamash Khadijah Saeed
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Al-Bishri Widad M.
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Abulnaja Khalid Omar
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Choudhry Hani
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Khan Jehan A.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Biological Sciences Department (Genomic division), Faculty of Science
Moselhy Said Salama 責任著者
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Department of Biochemistry, Faculty of Science, Ain Shams University
M Zamzami
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Kumosani Taha A.
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Production of Bioproducts for Industrial Applications Research Group
Al-Malki Abdulrahman L.
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Experimental Biochemistry Unit, King Fahd Medical Research Center
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Bioactive Natural Products Research Group
Alhosin Mahmoud
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Asami Tadao
Department of Biochemistry, Faculty of Science, King Abdulaziz University
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center
Graduate School of Agricultural and Life Sciences, The University of Tokyo

キーワード: cancer, phytohormones, synthetic SL analogues, GR24, MEB55, ST362, anti-cancer, apoptosis

ジャーナルフリー HTML

2018 年 43 巻 3 号 p. 168-172

DOI https://doi.org/10.1584/jpestics.D17-090

Browse “Advance online publication” version

詳細

抄録

化学療法は癌の抑制において効果的であるが，化学療法に対する耐性や重度の副作用が生じるために，その効果が制限される場合が多い．したがって，癌と戦うためには常に代替となる化学療法薬を見つける必要がある．植物は昔から医療に使用されてきており，19世紀の黎明期に見出された有望な抗癌剤の多くが植物に由来している．ストリゴラクトン（SL）は，シュートの分岐の調節に関与する新しい植物ホルモンである．最近，新規合成SL類縁体が固形腫瘍および非固形腫瘍に対して有効であることが見出された．これらの類縁体は，癌細胞の生存率を低下させ，アポトーシスおよび細胞死をマイクロモル濃度で促進する独特のメカニズムを有することが報告されている．したがって，合成SL類縁体は，将来有力な抗癌剤候補であり得る．これらの合成SL類類縁体の重要性を明らかにするためには，さらなる研究が必要である．

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）