超音波を用いた粉体圧縮成形機構と固体分散体形成への適用

抄録

Pharmaceutical applications of the ultrasound compacting method proposed by Rodriguez were investigated in this paper. It was found that the compression process of powder by irradiating ultrasound was different from that by direct compression. The decrease of porosity by the ultrasound irradiation was not caused by the elastic and plastic deformation of powder, but by the fusion of powder. The solid dispersions of indomethacin (IM) with various water-soluble polymers prepared by the ultrasound showed a more rapid dissolution behavior of IM than their simple physical mixtures. Compared with the grinding or heat-fusion method to prepare solid dispersion, the merits of the ultrasound method are that the fusion proceeds in a lower temperature and in a shorter period.