主催: Society for Reproduction and Development
Aflatoxin, a secondary metabolite of the mold Aspergillus flavus, has been reported to increase mortality, decrease body weight and induce severe oxidative stress in poultry production. Aflatoxin B1 (AFB1), as the most abundant and toxic form of aflatoxins, is hepatotoxic, hepa-tocarcinogenic, and teratogenic. As an essential nutrient, the trace mineral selenium (Se) is known as antioxidant and catalyst to animal biology. However, there is little report about the effect of Se on function of testes in broilers exposed to AFB1. The present study evaluated the protective effects of Se on attenuating the toxicity of AFB1 in broiler testes. Ninety 1-day-old broiler chickens were randomly allotted to 3 groups and treated as follows: basal diet (control), 100 μg AFB1 per 1 kg diet (AFB1), 100 μg AFB1 and 0.3 mg Se per 1 kg diet (AFB1+Se). Blood and testes were collected at day 42. The broilers fed AFB1 had lower levels in average daily gain (ADG), average final weight (AFW), average daily feed intake (ADFI) and liver organ index compared with control group. In serum, the content of glutamic pyruvic transaminase(GPT) and activity of total superoxide dismutase(T-SOD) were both decreased compared with control (P<0.05). There was an increasing trend in the activities of glutamic oxaloacetic transaminase(GOT) and γ-glutamyl transferase(γ-GT) in AFB1 group compared with control. In testes, catalase(CAT) activity in AFB1 group was much higher than the other two groups. These results suggested that AFB1 could induce oxidative stress in broiler testes. Se could efficiently protect the testis through partly reducing oxidative stress induced by AFB1 in broiler testes.
