抄録
In this work we wished to observe the effects of radioprotectors amifostine and WR151327 on incidence of non-lethal toxicities in mice exposed to radiation. STATA/SE 9 was used to examine the relationships between the incidence rates of non-lethal gross necropsy findings (NLGNs) in mice (B6CF1) irradiated with varying doses of gamma-rays or neutrons at Argonne National Laboratory from 1984-5. NLGNs included various tissue and organ problems including late tissue toxicities. A logistic regression using the presence of any NLGNFs as a positive outcome and a linear regression using the number of NLGNFs as the outcome value were performed. Control - gamma ray exposure comparison: Exposure to 206cGy yielded an increase in NLGNFs in the untreated group but not the group treated with amifostine, suggesting protective effects for amifostine at this dose. Control - neutron exposure comparison: Treatment with 10cGy significantly increased the average number of NLGNFs per mouse but not the probability of having a single NLGNF in both the untreated group and the group treated with WR151327 . Conversely, neither outcome was affected by a dose of 10cGy in the amifostine group. At an exposure level of 40cGy, neither radioprotector successfully eliminated the effects of irradiation on the number of NLGNFs, but amifostine eliminated the effect of the radiation on the binary outcome variable while WR151327 did not. Comparisons within radiation groups: There were no significant differences in NLGNF incidence between mice treated with 206cGy gamma radiation/no radioprotector and mice treated with 417cGy/amifostine and between mice treated with 10cGy neutron radiation/no radioprotector and mice treated with 40cGy/amifostine. Amifostine protected both gamma-ray and neutron exposed mice from developing non-lethal toxicities.
