Abstract
It is well known that the ad-sorption behavior of lymphocytes on materials is related to the material size as well as their surface chemical characteristics. To evaluate if the material size also affect the lymphocyte function, five different sizes of polypropylene fibers with the diameter ranging from 1.5μm to 17μm were cultured with murine lymphocytes. They were stimulated with Con A and the fiber size effect on lymphocytes were evalu-ated in terms of IL-2 production. Lymphocytes were adsorbed very efficiently only to fibers with diameters less than 10μm. Among the fibers which adsorbed lymphocytes, the IL-2 activity in the supernatant cultured with the finest fiber of 1.5μm showed the highest value, suaaestina possible size effect on the lymphocyte functions.
