Plasma-on-Chip: A microdevice for guiding cell fate

抄録

For changing and directing cell fate, various external stimuli have been used. Plasma, the fourth state of matter, has become available for those applications by recent technological advancement. In addition to selected cell killing and promotion of cell proliferation, plasma can be used to affect cell differentiation. To elucidate how plasma affects cell fate, a microdevice referred to as Plasma-on-Chip was developed. Cells in liquid medium can be located in the vicinity of gaseous plasma. The microdevice achieves direct plasma exposure of cultured cells by taking advantage of micro air–liquid interface for changing and directing cell fate. Here, results and future prospects of the Plasma-on-Chip are described.